Well, referring a bit to Speeder's first page post here, you need to set up every .exe files to run with Windows XP Service Pack 3 compatibility settings. It can be done by right click the file, open up the properties, then go to Compatibility, then set up which compatibility it should be running. You will want to do this on all three .exe files (syringe.exe, gamemd.exe and MentalOmegaClient.exe). You also need to run as Administrator
Ah, ok. I actually do recall doing this for yet another computer a long while back for vanilla YR, and that thought did come up... Though I dismissed it as the vanilla YR worked fine for this recent computer, and it was just the mod that didn't. One last question though: will changing the compatibility affect any other games or anything else? Thanks again.