Well, I don't know if this problem was posted before but here I go...
When I star the client everything is fine. But, when I try to play a skirmish or campaign the game just doesn't start (no error message, no nothing, just don't start) and then I'm back at the skirmish lobby or main menu if its a campaign mission. Here is the syringe.txt, hope it helps... since it has the save/load option I REALLY want to play.
Edit: Btw, I already tried rebooting.
I've encountered the same problem after my Windows 10 updated. The solution suggested by Speeder in the first post worked.
>>>Also set 'Run as Administrator' for gamemd.exe, Syringe.exe & MentalOmegaClient.exe.
>>>If it doesn't start matches, try rebooting your PC after setting all of these and see if it helps. If rebooting helped, let us know.
I've also set compatibility for all three files to Windows XP SP2. After rebooting the PC Mental Omega launched properly.